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KMID : 0356920190720050495
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Korean Journal of Anesthesiology
2019 Volume.72 No. 5 p.495 ~ p.499
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Anaphylactic shock after sugammadex administration, induced by formation of a sugammadex-rocuronium complex -a case report-
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Kim Gunn-Hee
Choi Won-Seop
Kim Ji-Eun
Yun Mi-Jung
Koo Min-Seok
Seo Hyung-Seok
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Abstract
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Background: Sugammadex is a reversal agent for non-depolarizing neuromuscular blockers and widely used worldwide on account of its rapid and effective reversal from neuromuscular blockade, despite its advantages, multiple cases of sugammadex-induced anaphylactic shock have been reported.
Case: A 42-year-old man developed anaphylactic shock in the postanesthesia care unit. Initially, sugammadex was suspected as the causative agent, but an intradermal skin test revealed negative results. A further skin test was performed with sugammadex-rocuronium complex that yielded positive results.
Conclusions: Anesthesiologists and healthcare providers should be aware of the possibility of anaphylaxis from the sugammadex-rocuronium complex, as well as from sugammadex or rocuronium alone.
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KEYWORD
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Anaphylactic shock, Cyclodextrin, Epinephrine, Hypersensitivity, Rocuronium, Sugammadex
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